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The use of trimetazidine to target the mitochondrial trifunctional fatty acid oxidation enzyme (MTP) disrupts the physical interaction between MTP and respiratory chain complex I while inhibiting oxidative phosphorylation, thereby inducing a redox imbalance and energy crisis in cancer cells [245]

doi: 10.1016/j.clnu.2012.02.001 Smith L: Overtraining, excessive exercise, and altered immunity: is this a T helper-1 versus T helper-2 lymphocyte response